Isoalantolactone alleviates ovalbumin-induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR-γ/KLF4 signals.

Autor:	Song, Yunduan, Li, Xiaozong, Liu, Fangfang, Zhu, Hongbo, Shen, Yao
Předmět:	OVALBUMINS PEROXISOME proliferator-activated receptors MACROPHAGES STAT proteins INFLAMMATION PLETHYSMOGRAPHY EOSINOPHILS IMMUNOGLOBULIN E
Zdroj:	Molecular Medicine Reports; Oct2021, Vol. 24 Issue 4, pN.PAG-N.PAG, 1p
Abstrakt:	Isoalantolactone (IAL), a sesquiterpene lactone, has anti-inflammatory activity in lipopolysaccharide (LPS)-induced sepsis. However, it remains to be elucidated whether IAL influences asthmatic inflammation. The present study found that IAL inhibited ovalbumin (OVA)-induced asthmatic inflammation and attenuated OVA-induced eosinophil infiltration, immunoglobulin E generation and the production of interleukin (IL)-4, IL-5, C-C motif chemokine ligand (CCL)17 and CCL22. In addition, IAL treatment with IL-4 reduced the expression of arginase-1, Ym-1, CCL17 and CCL22 in bone marrow-derived macrophages in vitro. Furthermore, IAL inhibited IL-4-induced STAT6 phosphorylation and the expression of peroxisome proliferator-activated receptor γ and Krüppel-like factor 4. Collectively, the results suggested that IAL attenuated asthmatic inflammation and is a potential therapeutic agent for the treatment of asthma. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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