| Autor: |
Xiong, Ling, Liu, Yanping, Liu, Ruchuan, Yuan, Wei, Wang, Gao, He, Yi, Shuai, Jianwei, Jiao, Yang, Zhang, Xixiang, Han, Weijing, Qu, Junle, Liu, Liyu |
| Předmět: |
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| Zdroj: |
Chinese Physics B; 9/15/2019, Vol. 28 Issue 10, p1-7, 7p |
| Abstrakt: |
Cancer cell motility and its heterogeneity play an important role in metastasis, which is responsible for death of 90% of cancer patients. Here, in combination with a microfluidic technique, single-cell tracking, and systematic motility analysis, we present a rapid and quantitative approach to judge the motility heterogeneity of breast cancer cells MDA-MB-231 and MCF-7 in a well-defined three-dimensional (3D) microenvironment with controllable conditions. Following this approach, identification of highly mobile active cells in a medium with epithelial growth factor will provide a practical tool for cell invasion and metastasis investigation of multiple cancer cell types, including primary cells. Further, this approach could potentially become a speedy (∼hours) and efficient tool for basic and clinical diagnosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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