| Autor: |
Pow, Robert W., Sinclair, Zoё L., Bell, Nicola L., Watfa, Nancy, Abul‐Haija, Yousef M., Long, De‐Liang, Cronin, Leroy |
| Předmět: |
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| Zdroj: |
Chemistry - A European Journal; 8/25/2021, Vol. 27 Issue 48, p12327-12334, 8p |
| Abstrakt: |
Determining the relative configuration or enantiomeric excess of a substance may be achieved using NMR spectroscopy by employing chiral shift reagents (CSRs). Such reagents interact noncovalently with the chiral solute, resulting in each chiral form experiencing different magnetic anisotropy; this is then reflected in their NMR spectra. The Keplerate polyoxometalate (POM) is a molybdenum‐based, water‐soluble, discrete inorganic structure with a pore‐accessible inner cavity, decorated by differentiable ligands. Through ligand exchange from the self‐assembled nanostructure, a set of chiral Keplerate host molecules has been synthesised. By exploiting the interactions of analyte molecules at the surface pores, the relative configuration of chiral amino alcohol guests (phenylalaninol and 2‐amino‐1‐phenylethanol) in aqueous solvent was establish and their enantiomeric excess was determined by 1H NMR using shifts of ΔΔδ=0.06 ppm. The use of POMs as chiral shift reagents represents an application of a class that is yet to be well established and opens avenues into aqueous host‐guest chemistry with self‐assembled recognition agents. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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