| Autor: |
Krokhicheva, P. A., Gol'dberg, M. A., Khairutdinova, D. R., Antonova, O. S., Akhmedova, S. A., Kirsanova, V. A., Sviridova, I. K., Sergeeva, N. S., Leonov, A. V., Baikin, A. S., Smirnov, I. V., Barinov, S. M., Komlev, V. S. |
| Zdroj: |
Russian Journal of Inorganic Chemistry; Aug2021, Vol. 66 Issue 8, p1079-1090, 12p |
| Abstrakt: |
In recent years, magnesium calcium phosphate materials have been considered as an alternative to calcium phosphate-based materials in reconstructive surgery. In this work, bone cements in the calcium phosphates–magnesium phosphates system were synthesized and studied. The interaction of this system with a cement liquid gives struvite MgNH4PO4·6H2O as the main phase. The obtained materials have a compressive strength of up to 54 ± 5 MPa, a setting time of 6–7 min, and a neutral pH value. The effect of the introduction of vancomycin to the cement materials was studied. Investigation of the kinetics of vancomycin release showed that up to 98% of the antibiotic is released within 21 days. The materials exhibited pronounced antibacterial activity against the Staphylococcus aureus and Escherichia coli strains. After the introduction of vancomycin, the zone of inhibition of bacterial growth more than doubled compared to the reference samples. In vivo tests were conducted, the structural factors were calculated based on the results of micro-CT. According to macro and micro signs, the cement materials are fully biocompatible; by the sixth week, the formation of new bone tissue is observed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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