| Autor: |
ЛУКАЧ, Е. В., САМБУР, М. Б., ФЕДОРЕНКО, З. П., СЕРЕЖКО, Ю. О. |
| Zdroj: |
Otorhinolaryngology (25288253); 2019, Issue 4/5, p58-66, 9p |
| Abstrakt: |
The authors analyze the epidemiological indicators of morbidity, mortality, age structure, relative number of patients detecting during prophylactic examination and contingent of patients with malignant neoplasms (MN) of the throat in Ukraine and regions according to the Bulletin of National Cancer Registry of Ukraine in 2014-2018 The highest incidence rate per 100,000 population in the regions of Ukraine was found in Transcarpathian (both sexes - 9.6; males - 17.9; females - 2.0), Kirovograd (8.8; 16.9; 1.9) and Khmelnitsky (7.7; 15.9; 0.7) regions Very low rates of detection of patients with MN of the throat as a whole in Ukraine were observed at the prophylactic examinations: in 2015 - 10.0%, in 2016 - 11.0% Annually in Ukraine, about 44.0% of patients with visually detectable cancer of the pharynx die within 1 year of diagnosis The mortality rate of patients with MN of the throat in 2017 per 100 thousand population of Ukraine is twice higher (4.5) than the world standard (2.0) The etiological factors that cause cancer and the role of human papilloma virus (HPV) of high oncogenic risk (16; 18 and other types) in the carcinogenesis of squamous cell carcinoma of the throat are considered The data on genetic factors, features of gene mutation, clinical course, treatment and prognosis in patients with HPV-associated and HPV-negative malignancies of the pharynx are presented. For the prevention of pharyngeal cancer in Ukraine, the feasibility of immunization of children and young women aged 9-25 years with vaccines against HPV "Cervarix" and "Gardasil" is discussed. The authors have proposed suggestions for the early detection and improvement of the effectiveness of treatment of patients with pharyngeal throat. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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