| Autor: |
ЗАБОЛОТНЫЙ, Д. И., САМБУР, М. Б., ВОРОШИЛОВА, Н. В., ВЕРЕВКА, С. В. |
| Zdroj: |
Otorhinolaryngology (25288253); 2019, Issue 2/3, p72-84, 13p |
| Abstrakt: |
Permanent character of the improvement of resistance of living organisms to the influence of adverse environmental factors is an integral property of evolution. One of the manifestiations of this improvement is the formation of the resistance of pathogens to antibiotics. The speed of formation and spread of resistant pathogens complicates the treatment of diseases and creates the danger of discarding of clinical medicine in the pre-antibiotic era. The situation is complicated by the possibility of the formation of multiresistance, which is the resistance of microbiological pathogens to different types of antibiotics. Similarly to the most of microorganisms, bacterial infectious agents exist mainly in the form of biofilms - three-dimensional associate of microorganisms that are fixed by a matrix from an extracellular polymeric substance, which is synthesized by the cells themselves. The main topics of this work are the roles of extracellular components of biofilms in the formation of antibiotic resistance, the need for permanent death of the part of the cells for survive of the community of microorganisms, and the effect of decay products on the adjacent tissues as the premise for the chronicity of the inflammatory process. The prospects of ultrasound destruction of biofilms for the suppression of antibiotic resistance and the prevention of chronic inflammation are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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