| Autor: |
Akindele, Nadine Peart, Kouo, Theodore, Karaba, Andrew H, Gordon, Oren, Fenstermacher, Katherine Z J, Beaudry, Jeanette, Rubens, Jessica H, Atik, Christine C, Zhou, Weiqiang, Ji, Hongkai, Tao, Xueting, Vaidya, Dhananjay, Mostafa, Heba, Caturegli, Patrizio, Blair, Paul W, Sauer, Lauren, Cox, Andrea L, Persaud, Deborah, Peart Akindele, Nadine |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 8/15/2021, Vol. 224 Issue 4, p606-615, 10p |
| Abstrakt: |
Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe clinical phenotype of SARS-CoV-2 infection that remains poorly understood.Methods: Hospitalized children <18 years of age with suspected COVID-19 (N=53) were recruited into a prospective cohort study; 32 had confirmed COVID-19, with 16 meeting the U.S. Centers for Disease Control criteria for MIS-C. Differences in nasopharyngeal viral RNA levels, SARS-CoV-2 seropositivity, and cytokine/chemokine profiles were examined, including after adjustments for age and sex.Results: The median ages for those with and without MIS-C were 8.7 years (IQR 5.5-13.9) and 2.2 years (IQR 1.1-10.5), respectively, (p=0.18) and nasopharyngeal levels of SARS-CoV-2 RNA did not differ significantly between the two groups (median 63,848.25 copies/mL versus 307.1 copies/mL, p= 0.66); 75% of those with MIS-C were antibody positive compared to 44% without, p=0.026. Levels of 14 of 37 cytokines/chemokines (IL-1RA, IL-2RA, IL-6, IL-8, TNF-α, IL-10, IL-15, IL-18, MCP-1, IP-10, MIP-1α, MCP-2, MIP-1β, Eotaxin) were significantly higher in children with MIS-C compared to those without, irrespective of age or sex (FDR<0.05; p<0.05).Conclusions: The distinct pattern of heightened cytokine/chemokine dysregulation observed with MIS-C, compared with acute COVID-19, occurs across the pediatric age spectrum and with similar levels of nasopharyngeal SARS-CoV-2 RNA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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