| Autor: |
Pandrowala, Saneya, Jones, Robin L, Gupta, Sanjay, Gulia, Ashish |
| Zdroj: |
Future Oncology; Aug2021, Vol. 17 Issue 25, p3397-3408, 12p |
| Abstrakt: |
Desmoid fibromatosis is a locally aggressive tumor with an unpredictable clinical course. Surgery was once the mainstay of treatment, but the treatment protocol has been constantly evolving and currently active surveillance is the front-line approach. There have been significant insights into the molecular biology with the addition of mutational analysis of CTNNB1 adding to prognostic information. We present a review of the literature with current practice guidelines, also including novel therapeutic targets and ongoing clinical trials, to unravel the next step in the management of sporadic desmoid fibromatosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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