Regioselective synthesis of kojic acid esters by Bacillus subtilis protease.

Autor:	Raku, Takao, Tokiwa, Yutaka
Předmět:	BACILLUS subtilis PROTEOLYTIC enzymes ESTERS SOLUBILITY PHENOL oxidase BIODEGRADATION
Zdroj:	Biotechnology Letters; Jun2003, Vol. 25 Issue 12, p969-974, 6p
Abstrakt:	The lipophilicity of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one] was improved by esterifying kojic acid with either divinyl adipate, vinyl hexanoate, vinyl octanoate or vinyl decanoate using protease from Bacillus subtilis for 7 d. 1H-NMR and 13C-NMR showed that the primary hydroxyl group at the C-7 position of kojic acid was regioselectively esterified to afford 7-O-vinyl adipoyl kojic acid, 7-O-hexanoyl kojic acid, 7-O-octanoyl kojic acid and 7-O-decanoyl kojic acid (13–27% yield). The kojic acid esters had radical scavenging activities, inhibited tyrosinase activity and was biodegradable. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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