| Autor: |
Anggraeny, Ebta Narasukma, Cahyani, Intan Martha, Retnaningsih, Christiana, Ananingsih, Victoria Kristina, Prahasiwi, Masitoh Suryaning, Nugraheni, Bekti, Indah Sari, Afri Diyah Nur |
| Předmět: |
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| Zdroj: |
Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia; Jan-Mar2021, Vol. 32 Issue 1, p126-131, 6p |
| Abstrakt: |
Diabetes mellitus is a common metabolic disease marked by hyperglycemia which is also caused by oxidative stress. The administration of antioxidants coming from food or supplements can inhibit the formation of free radicals. Clinacanthus nutans has been reported to possess various medicinal advantages such as blood glucose lowering effect, alphaglucosidase inhibition activity, antioxidant activities, anti-cancer properties, and anti-inflammatory effects. However, C. nutans leaf extracts fractions has several limitations, i.e. highly viscous that may constraint its pharmaceutical formulation as well as the astringent and bitter taste which diminish its oralbased formulation. In order to solve this problem, microencapsulation strategy during formulation can be used here in. The purpose of this research is to find the blood glucose level lowering effect of the aqueous fraction of microcapsules and to find the effective dose on fructose and fat-induced Wistar strain rat. The induction was done using fructose and high-fat feed for 55 days. Rats were divided into 8 groups: normal control (aquadest), negative control (Arabic gum and maltodextrin), positive control (metformin), dose I (15.89 mg/kg BW microcapsule of aqueous fraction of Clinacanthus nutans extract), dose II (31.78 mg/kg BW), dose III (47.67 mg/kg BW), dose IV (63.56 mg/kg BW), and dose V (79.45 mg/kg BW). The result showed that the microcapsules of the aqueous fraction of Clinacanthus nutans (Burm.f) extract could lower Wistar strain rat blood glucose level in the dose of 15.89 mg/kg of the rat's body weight. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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