Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic.

Autor:	Tsuneki-Tokunaga, Akeno, Kanai, Kyosuke, Itagaki, Asao, Tsuchie, Hideaki, Okada, Takayoshi, Kasagi, Masaaki, Tanaka, Kiyoshi, Aoki, Miho, Hinay, Alfredo Jr. A., Kageyama, Seiji
Předmět:	INFLUENZA viruses INFLUENZA A virus PANDEMICS INFLUENZA A virus H1N1 subtype EPIDEMICS VIRAL load PROGNOSIS
Zdroj:	Archives of Virology; Apr2021, Vol. 166 Issue 4, p1193-1196, 4p
Abstrakt:	The correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth capability (104–1011 copies/mL) in Madin-Darby canine kidney cells. The growth was correlated with the nasopharyngeal viral load (r = 0.53). Six selected strains showed growth-dependent cell death (r = 0.96) in a growth kinetics assay. Epidemic influenza viruses exhibit a wide range of growth capability. Growth capability should be considered one of the key factors in disease prognosis. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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