| Autor: |
Bochkarev, P. Yu., Berdyugina, O. V., Zhidkova, V. S., Zubova, T. E., Gusev, E. Yu. |
| Předmět: |
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| Zdroj: |
Neuroscience & Behavioral Physiology; Jun2021, Vol. 51 Issue 5, p565-569, 5p |
| Abstrakt: |
Ojecive. To identify the probability that systemic inflammation (SI) would develop as a general pathological process in severe intracranial hemorrhagic stroke with and without the phenomenon of ineffective brain blood flow. Materials and methods. Three groups were studied: 1) 89 blood donors (controls); 2) 15 patients with severe hemorrhagic stroke without the ineffective blood flow phenomenon; 3) 26 patients with severe hemorrhagic stroke with ineffective brain blood flow. Ineffective brain blood flow was recorded using transcranial dopplerography data and 87% of these patients had clinical signs of brain death. All patients in groups with hemorrhagic stroke were shown on the Sepsis-Related Organ Failure scale to have signs of multiorgan failure and all received intensive therapy. Systemic inflammation was confirmed using an integral scale based on determination of plasma cytokine (IL-6, IL-8, IL-10, TNF-α), procalcitonin, cortisol, D-dimers, myoglobin, and troponin I levels. Results. Systemic inflammation or a borderline state (pre-SI) was found in all patients of group 2 on investigation both 1–3 days and 5–8 days from the onset of signs of hemorrhagic stroke. Conversely, signs of SI in group 3 were not present on days 1–3, though signs of SI and pre-SI were present in only 18.2% of patients on days 5–8. The cause of these differences appeared to be blockade of the transfer of tissue degradation products and proinflammatory factors from damaged brain tissue to the circulation in group 3. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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