Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Autor: | Cheng, Dan, Su, Lei, Wang, Xu, Li, Xinjie, Li, Lingling, Hu, Mengyuan, Lu, Yi |
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Předmět: |
CALCIUM metabolism
HOMEOSTASIS IN vitro studies ADENOSINE triphosphate FLOW cytometry STATISTICS MEDICINAL plants ALZHEIMER'S disease HERBAL medicine HIGH performance liquid chromatography ANIMAL experimentation BIOLOGICAL transport WESTERN immunoblotting ONE-way analysis of variance FLUORESCENCE spectroscopy MITOCHONDRIA GENE expression CELL survival ELECTRON microscopy DESCRIPTIVE statistics RESEARCH funding PLANT extracts CELL lines REACTIVE oxygen species DATA analysis software DATA analysis MOLECULAR structure CHINESE medicine MICE PHOSPHORYLATION |
Zdroj: | BMC Complementary Medicine & Therapies; 8/9/2021, Vol. 21, p1-14, 14p, 1 Color Photograph, 1 Diagram, 2 Charts, 7 Graphs |
Abstrakt: | Background: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, but there is still no effective way to stop or slow its progression. Our previous studies demonstrated that extract of Cynomorium songaricum (ECS), a Chinese herbal medicine, had neuroprotective effects in AD models in vivo. However, the pharmacological mechanism of ECS in AD is still unclear. Methods: To study the mechanisms of action of the effects of ECS on AD, we used Aβ |
Databáze: | Complementary Index |
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