Effect of Constant Rate Infusion of Tramadol-Xylazine and Pentazocine Xylazine on Acute Pain Response in Xylazine-Pentobarbitone Anaesthetized Dogs Undergoing Digital Amputation.

Autor: Udegbunam, Ijeoma R., Ogbodo, Frank U., Onuba, Chukwudum A., Okereke, Nnamdi H., Ezeobialu, Toochukwu H., Udegbunam, Sunday O.
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Zdroj: Alexandria Journal of Veterinary Sciences; Jul2021, Vol. 70 Issue 1, p140-150, 11p
Abstrakt: The study evaluated the effect of constant rate infusion of tramadol-xylazine and pentazocine-xylazine on pain in dogs undergoing digital amputation. Twelve mongrel used for the study were randomly assigned to four groups (n=3). Group 1 received loading dose (LD) Xylazine (1mg/kg IV) and Pentobarbitone sodium (Na) (30mg/kg IV) [LD-XP] prior to digital amputation (DA).Group 2 received LD-XP andXylazine (1mg/kg/hr) by constant rate infusion (CRI IV) prior to DA. Group 3 received LD Xylazine (1mg/kg IV), Pentobarbitone Na (30mg/kg IV), CRI Xylazine (1mg/kg/hr) and Tramadol (1mg/kg/hr) prior to DA. Group 4 received LD-XP, CRI Xylazine (1mg/kg/hr) and CRI Pentazocine (1mg/kg/hr) prior to DA. Results of the pain score evaluation showed that at 1, 3, 6 and 24 hours post-surgery (PS), group 4 had the lowest (p<0.05) pain score followed by group 3. Group 4 animals had a significantly (p<0.05) higher heart rate and pulse rate values at 3 and 120 hours. The respiratory rate of group 4 was significantly higher (p<0.05) when compared with the other groups at 3 and 24 hours. It was concluded that CRI pentazocine-xylazine provided better analgesia in the dog DA model. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index