| Autor: |
Ahmed, Nihad Hussein, Kadhim Al-Zubaidy, Adeeb Ahmed, Qasim, Ban Jumaah |
| Předmět: |
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| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Jul-Sep2021, Vol. 15 Issue 3, p1572-1577, 6p |
| Abstrakt: |
To evaluate the possible beneficial effect of tadalafil gel(0.05%) in imiquimod-induced psoriasiform skin inflammation in mice model. forty male BALB/c albino mice with age range of 8-11 weeks and weight ranged 25-40 g; were divided equally into four groups (ten mice / group) after their skin of dorsal back and right ear being shaved for topical application: Group I (normal control) healthy mice without treatment. Group II (Induction group) in which mice received only a daily topical dose of 62.5mg of imiquimod cream (5%) for seven days. The following groups (III and IV), after being received imiquimod cream (5%) as mentioned in induction group, mice were treated for further two weeks with either clobetasol ointment (0.05%) topically once daily (clobetasol group), tadalafil gel (0.05%) topically once daily(tadalafil gel group) Table(1) showed a significant elevation of tissue TNF-α and IL17 with a highly significant increase in IL23 and VEGF levels beside a reduction in the level of TGF-β in induction group as compared to normal control group . Clobetasol group treated displayed a highly significant reduction in TNF-α, IL-17, and VEGF levels beside a reduction in IL-23 and no significant difference in the level of TGF-β when being compared to induction group (table 2). This study demonstrated a significant reduction in both TNF-α and IL-17, with a highly significant decrease in IL23 level. Beside a no significant decrease in both VEGF and of TGF-β levels in tadalafil gel group in comparison with induction group. The possible effect of anti-inflammatory activity of tadalafil gel on the skin homogenate parameters in imiquimod-induced psoriasiform skin inflammation in mice model. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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