| Autor: |
Abdul Aemah, Maytham Ahmed, Al-Gazally, Moaed Emran, Al-Sultani, Ali Jasim |
| Předmět: |
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| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Jul-Sep2021, Vol. 15 Issue 3, p1084-1093, 10p |
| Abstrakt: |
Concerning type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN) is a chiefmicrovascular complication. Preceding studies have proposed that insulin-like growth factor-1(IGF-1) signaling might do a significant role in DN. The existing study was implemented to explorethe allianceof single nucleotide polymorphism (SNP) rs6214 of the IGF-1gene with T2DM and DN. The study consists of three groups, the first oneincludes 50 subjects, those were apparently healthy were considered as controls. The second oneinvolves 69 patients with T2DM without nephropathy and the third oneencompasses 89 patients who suffer from T2DM with DN. The analysis of results elucidated that thegenotype CT was decided to significantly increase the hazard of T2DM by about 2 folds and the genotype TT was established to significantly increase the risk of DN by about 3 folds with respect to those of the genotype CC. This study concludes that theSNPrs6214 of theIGF-1 gene associated with T2DM and DN. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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