| Autor: |
Wu, Yangtao, Huang, Xiaofen, Yuan, Lunzhi, Wang, Shaojuan, Zhang, Yali, Xiong, Hualong, Chen, Rirong, Ma, Jian, Qi, Ruoyao, Nie, Meifeng, Xu, Jingjing, Zhang, Zhigang, Chen, Liqiang, Wei, Min, Zhou, Ming, Cai, Minping, Shi, Yang, Zhang, Liang, Yu, Huan, Hong, Junping |
| Zdroj: |
Science Translational Medicine; 8/11/2021, Vol. 13 Issue 606, p1-15, 15p |
| Abstrakt: |
Tackling transmission: An important feature of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is whether or not the vaccine prevents transmission to others. In this study, Wu et al. vaccinated mice, hamsters, and cynomolgus monkeys with a SARS-CoV-2 spike protein subunit vaccine, StriFK, plus a nitrogen bisphosphonate–modified zinc-aluminum hybrid adjuvant called FH002C. The vaccine elicited antibody and cell-mediated immunity in all three models. StriFK-FH002C vaccination prevented hamsters from transmitting virus to unvaccinated, cohoused hamsters. This was associated with lower viral load in the upper respiratory tract of vaccinated hamsters after challenge. Thus, StriFK-FH002C represents an effective vaccine candidate for SARS-CoV-2. Multiple safe and effective vaccines that elicit immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary to respond to the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a protein subunit vaccine composed of spike ectodomain protein (StriFK) plus a nitrogen bisphosphonate–modified zinc-aluminum hybrid adjuvant (FH002C). StriFK-FH002C generated substantially higher neutralizing antibody titers in mice, hamsters, and cynomolgus monkeys than those observed in plasma isolated from COVID-19 convalescent individuals. StriFK-FH002C also induced both TH1- and TH2-polarized helper T cell responses in mice. In hamsters, StriFK-FH002C immunization protected animals against SARS-CoV-2 challenge, as shown by the absence of virus-induced weight loss, fewer symptoms of disease, and reduced lung pathology. Vaccination of hamsters with StriFK-FH002C also reduced within-cage virus transmission to unvaccinated, cohoused hamsters. In summary, StriFK-FH002C represents an effective, protein subunit–based SARS-CoV-2 vaccine candidate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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