| Autor: |
Di Mascio, Daniele, Herraiz, Ignacio, Villalain, Cecilia, Buca, Danilo, Morales-Rossello, Jose, Loscalzo, Gabriela, Sileo, Filomena Giulia, Finarelli, Alessandra, Bertucci, Emma, Facchinetti, Fabio, Rizzo, Giuseppe, Brunelli, Roberto, Giancotti, Antonella, Muzii, Ludovico, Maruotti, Giuseppe Maria, Carbone, Luigi, D'Amico, Alice, Tinari, Sara, Morelli, Roberta, Cerra, Chiara |
| Předmět: |
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| Zdroj: |
Fetal Diagnosis & Therapy; 2021, Vol. 48 Issue 6, p448-456, 9p |
| Abstrakt: |
Introduction: The role of cerebroplacental ratio (CPR) or umbilicocerebral ratio (UCR) to predict adverse intrapartum and perinatal outcomes in pregnancies complicated by late fetal growth restriction (FGR) remains controversial. Methods: This was a multicenter, retrospective cohort study involving 5 referral centers in Italy and Spain, including singleton pregnancies complicated by late FGR, as defined by Delphi consensus criteria, with a scan 1 week prior to delivery. The primary objective was to compare the diagnostic accuracy of the CPR and UCR for the prediction of a composite adverse outcome, defined as the presence of either an adverse intrapartum outcome (need for operative delivery/cesarean section for suspected fetal distress) or an adverse perinatal outcome (intrauterine death, Apgar score <7 at 5 min, arterial pH <7.1, base excess of >−11 mEq/mL, or neonatal intensive care unit admission). Results: Median CPR absolute values (1.11 vs. 1.22, p = 0.018) and centiles (3 vs. 4, p = 0.028) were lower in pregnancies with a composite adverse outcome than in those without it. Median UCR absolute values (0.89 vs. 0.82, p = 0.018) and centiles (97 vs. 96, p = 0.028) were higher. However, the area under the curve, 95% confidence interval for predicting the composite adverse outcome showed a poor predictive value: 0.580 (0.512–0.646) for the raw absolute values of CPR and UCR, and 0.575 (0.507–0.642) for CPR and UCR centiles adjusted for gestational age. The use of dichotomized values (CPR <1, UCR >1 or CPR <5th centile, UCR >95th centile) did not improve the diagnostic accuracy. Conclusion: The CPR and UCR measured in the week prior delivery are of low predictive value to assess adverse intrapartum and perinatal outcomes in pregnancies with late FGR. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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