| Autor: |
Hidaka, Teruyuki, Anai, Hiroshi, Sakaguchi, Hiroshi, Sueyoshi, Satoru, Tanaka, Toshihiro, Yamamoto, Kiyosei, Morimoto, Kengo, Nishiofuku, Hideyuki, Maeda, Shinsaku, Nagata, Takeshi, Kichikawa, Kimihiko |
| Předmět: |
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| Zdroj: |
Minimally Invasive Therapy & Allied Technologies; Aug2021, Vol. 30 Issue 4, p221-228, 8p |
| Abstrakt: |
To assess the efficacy of combined therapy involving bland transarterial embolization using gelatin sponge particles (bland GS-TAE) followed by transarterial chemoembolization using lipiodol mixed with anticancer agents and GS particles (Lip-TACE) to reduce the adverse events and increase the therapeutic effect of Lip-TACE in the treatment of huge (≥10 cm) hepatocellular carcinoma (HCC). Twenty-one consecutive patients with huge HCCs (≥10 cm in diameter) were enrolled in this study. First, bland GS-TAE was performed to reduce the tumor volume, and then Lip-TACE was performed to control the remaining tumor at intervals of around three weeks. Tumor response, survival, and adverse events of this combined therapy were assessed. The tumor response was assessed three months after combined TACE, with complete response in 38.1% and partial response in 57.1% of cases. Severe adverse events were seen in two patients, acute cholecystitis and tumor rupture. The median survival time was 2.7 years, and the one-, two-, three-, and five-year overall survival rates were 76.2%, 66.7%, 42.9%, and 25.0%, respectively. Combined therapy involving bland GS-TAE followed by Lip-TACE can be performed safety and may improve survival in patients with huge HCCs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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