| Autor: |
Zhong, Junping, Chen, Jinying, Tan, Haishu, Chen, Guojie, Han, Dingan, Wang, Mingyi, Xiong, Honglian, Wang, Xuehua, Zeng, Yaguang |
| Předmět: |
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| Zdroj: |
AIP Advances; Jul2021, Vol. 11 Issue 7, p1-6, 6p |
| Abstrakt: |
Probe-assisted integration of imaging and therapy into a single modality provides tremendous opportunities in biological applications. In this study, phase-transition-mediated cavitation was used for simultaneous photoacoustic imaging (PA) and triggering drug release. For this purpose, we developed unique phase-transition mesoporous silicon nanoprobes (ICG/PFC/PTX@MSNs) consisting of indocyanine green (ICG), perfluorocarbon (PFC), and paclitaxel (PTX). For high-dose laser irradiation, the encapsulated ICG absorbs laser energy, providing localized heating well over the supercritical temperature of PFC. Then, liquid PFC was subjected to a liquid-to-gas phase transition, which generated stronger PA signals and promoted fast drug release. The enhancement of ICG/PFC/PTX@MSNs for PA imaging was demonstrated in in vitro and in vivo experiments. The average PA signal based on the phase-transition mechanism was ∼3 times higher than that of the traditionally used thermal expansion mechanism. Furthermore, the rapid drug release based on the same phase-transition-mediated cavitation mechanism can be achieved simultaneously; eventually, ∼80.4% of the total encapsulated drug were released. The hematoxylin–eosin stained section of tumor tissues from the ICG/PFC/PTX@MSN group showed many dead cells with condensed nuclei and pyknosis. This method not only promotes efficacy of chemotherapy but also makes accurate imaging-guided chemotherapy possible. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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