Effects of sulphur-containing mineral water intake on oxidative status and markers for inflammation in healthy subjects.

Autor: Sokrateva, Todorka D., Roussev, Bogdan H., Nashar, Milka A., Kiselova-Kaneva, Yoana D., Mihaylova, Galya M., Todorova, Miglena N., Pasheva, Milena G., Tasinov, Oskan B., Nazifova-Tasinova, Neshe F., Vankova, Deyana G., Ivanova, Desislava P., Radanova, Maria A., Ts. Galunska, Bistra, Vlaykova, Tatyana I., Ivanova, Diana G.
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Zdroj: Archives of Physiology & Biochemistry; Aug2021, Vol. 127 Issue 4, p327-336, 10p
Abstrakt: Sulphurous mineral waters (SMW) have a wide range of applications. Sulphur content of mineral waters is considered as possible determinant for their anti-inflammatory or pro-inflammatory effects. To explore the healing properties of Varna basin mineral water by analysing possible antioxidative and anti-inflammatory effects. An intervention with Varna SMW intake was performed with healthy volunteers. Total thiols, total glutathione and its fractions, reactive oxygen metabolites, malondialdehyde, intracellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) were measured. Expression of γ-gluthamyl-cysteinyl ligase (GCL) and sICAM-1 genes was also analysed. A significantly increased total glutathione and total thiols were observed at the end of the intervention. GCL and sICAM-1 gene expressions were increased after the intervention. SMW consumption improved redox status of the body. We suggested that these beneficial effects may be attributed to the established high levels of sulphur-containing compounds in Varna mineral water. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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