| Autor: |
Grønlund, Casper, Devantier, Louise, Callesen, Henriette Edemann, Hougaard, Dan Dupont, Händel, Mina Nicole, Schmidt, Jesper Hvass, Guldfred, Frank Liviu-Adelin, Djurhuus, Bjarki Ditlev |
| Předmět: |
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| Zdroj: |
International Archives of Otorhinolaryngology; 2021, Vol. 25 Issue 3, p463-470, 8p |
| Abstrakt: |
Introduction Menière disease (MD) is a disorder characterized by episodes of vertigo, sensorineural hearing loss, tinnitus and aural fullness. Objectives To assess the effect of ventilation tube insertion (VTI) on vertiginous episodes in patients (≥ 18 years old) with MD. Data Synthesis A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to assess the overall certainty of evidence. TwoRCTs and fournonrandomizedstudieswere identified. Data extractionwas only possible for one RCT.Results showed that the numberof patientswithnovertigo attacks significantly increased following active treatment (relative risk 1.52; [95% confidence interval: 1.19-1.94]). The quality of evidence was rated as low. None of the nonrandomized trials included a proper control group, which hindered data extraction and quality assessment. Conclusion There are currently no RCTs that specifically assess the efficacy of VTI in patients withMD.Current limited data suggest a considerable positive effecton the number of vertiginous episodes in patients with MD. However, due to poor evidence, a fluctuating course and a substantial placebo-effect associated with MD-treatment, no solid conclusion (s) regarding the efficacy of VTI can be made. There is a need for high-quality RCTs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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