| Autor: |
Lesmana, M. A., Dewi, A. H. K., Mahdi, C., Vidiastuti, D., Noviatri, A., Fauzi, A., Permata, S. P. |
| Předmět: |
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| Zdroj: |
Veterinary Practitioner; 2020 Supplement, Vol. 21, p372-375, 4p |
| Abstrakt: |
Insecticides are chemicals that characterized as toxic and used to eliminate insects, the most often used insecticides is deltamethrin. Deltamethrin commonly used in agriculture and veterinary field. Intoxication of deltamethrin can cause oxidative damaged and increased malondyaldehides level in tissue. Artemisia vulgaris extract has potential to reduce toxicity of deltamethrin with high flavonoid contents. Flavonoid has power to break up free radicals by transferring one of the hydrogen atom or electron transfer system, that could immedietly reduce the production of Reactive Oxygen Species (ROS). This research intends to know the preventive effect of Artemisia vulgaris extract to reduce MDA (malondialdehyde) level and histopathological damage in rat's kidney that was induced by deltamethrine. This research is using completely randomized design (CRD) with five treatment group, as positive control, negative control, preventive treatment group with extract dosage 150 mg/kg b.wt., 300 mg/kg b.wt., and 600 mg/kg b.wt. Deltamethrin induction is done intraperitoneally with dosage 7.2 mg/kg b.wt., MDA level done by TBA (thiobarbituric acid) methods and histopathology colored by Hematoxylin Eosin (HE). The study shows that preventive treatment group by Artemisia vulgaris extract with dosage 150 mg/kgBB, 300 mg/kg b.wt. and 600 mg/kg b.wt. shown very real result (P<0.01) with rat that induced by deltamethrin. Histopathological of rat's kidney observation shows that preventive treatment group by Artemisia vulgaris extract with dosage 150 mg/kg b.wt. 300 mg/kg b.wt. and 600 mg/kg b.wt. can obtruct glomerular atrophy, tubule dilatation and haemorraghic in kidney, we can conclude that preventive treatment of Artemisia vulgaris extract to rat indunced by deltamethrin can prevent raising of MDA level and can prevent cell damage in kidney cell of rat (Rattus norvegicus). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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