| Autor: |
Avcıbaşı, Uğur, Türkyarar, Taner, Karadağ, Ayşegül, Bakan, Buket, Yavaşoğlu, Nefise Ülkü Karabay, Kuşat, Kevser, Akgöl, Sinan, Gülcemal, Derya, Tekin, Volkan, Müftüler, Fazilet Zümrüt Biber, Topal, Gökcen, Parlak, Yasemin, Gümüşer, Fikriye Gül |
| Předmět: |
|
| Zdroj: |
Journal of Radioanalytical & Nuclear Chemistry; Aug2021, Vol. 329 Issue 2, p511-525, 15p, 2 Color Photographs, 2 Black and White Photographs, 1 Diagram, 3 Charts, 7 Graphs |
| Abstrakt: |
The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with 99mTc. The radiochemical yield of approximately the 99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
