IL-17, A Possible Salivary Biomarker for Preterm Birth in Females with Periodontitis.

Autor: Mahilkar, Sonal, Malagi, Sachin K., Soni, Abhishek, Abraham, Dennis V., Johnson, Lynn, Pattanshetti, Kirti S.
Zdroj: Journal of Obstetrics & Gynecology of India; Jun2021, Vol. 71 Issue 3, p262-267, 6p
Abstrakt: Background: Previous studies have suggested that chronic periodontal infection may be associate with preterm births and low birth weight. The present study was conducted to evaluate the levels of interleukin-17 (IL-17) in saliva samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Aim: The aim of the study is to assess the relation between the periodontal health status and preterm low birth weight of the new born on the basis of salivary IL-17 levels. Materials and Methods: This case–control study included a random sample of 40 female patients, aged 18 to 35 years, who were in their second trimester, assigned to two groups, Group 1 consisted of 20 pregnant females without periodontitis, Group 2 included 20 pregnant females with periodontitis. Saliva samples were obtained in the second trimester and postpartum. Saliva samples were measured by using ELISA for IL-17 levels. Results: IL-17 levels in saliva were significantly higher in Group 2 than that of Group 1(p < 0.001). There was no significant difference found between the preterm and low birth weight cases and periodontitis. Conclusion: This study did not find any association between the periodontitis and preterm deliveries and low birth weight cases on the basis of IL-17 levels in saliva. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index