| Autor: |
Fong, Tse-Ling, Lee, Brian T., Chang, Mimi, Nasanbayar, Khishigsuren, Tsogtoo, Enkhjargal, Boldbaatar, Delgerbat, Dashdorj, Esugen D., Clifford, Namuun E., Dashdorj, Arghun N., Bang, Bo-Ram, Chida, Takeshi, Lim, Carolina, Sugiyama, Masaya, Mizokami, Masashi, Dashdorj, Naranjargal J., Liu, Ping, Glenn, Jeffrey S., Dashdorj, Naranbaatar D., Saito, Takeshi |
| Předmět: |
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| Zdroj: |
Digestive Diseases & Sciences; Aug2021, Vol. 66 Issue 8, p2833-2839, 7p |
| Abstrakt: |
Background: Mongolia is a highly endemic region for chronic hepatitis B (HBV), hepatitis delta (HDV), and hepatitis C (HCV) infections. Aim of this study was to comprehensively characterize chronic viral hepatitis among Mongols living in Southern California. Methods: Three screening events were conducted between August and November 2018, with 528 adult Mongols tested for HBV and HCV. HBsAg (+) individuals (CHB) underwent additional testing for HDV RNA and anti-HDV. Liver tests, platelet count, and FibroScan™ were performed on CHB and chronic HCV (CHC) individuals. Results: Fifty-one out of 534 were HBsAg reactive (9.7%), and all were foreign-born. Mean age of CHB individuals was 37.8 (range 18–69) years. Forty-six out of 51 were HBeAg (–). HBV genotypes were exclusively D2 or A1. Twenty-one out of 51 (41.2%) were anti-HDV (+) and 17/51 (33.3%) were HDV RNA (+). HDV RNA (+) individuals had significantly higher ALT, fibrosis-4 score, and liver stiffness compared to HDV RNA (–) individuals. Incidence of advanced fibrosis was higher in HDV RNA (+) individuals (57% vs. 13%, p = 0.013). Forty-eight (9.1%) individuals were anti-HCV (+) and 19 (3.6%) were HCV RNA (+). Mean age of CHC individuals was 40.2 (range 28–71) years. Prevalence of anti-HCV (+) was higher among those born between 1945 and 1965 versus those born after 1965 (18.8% vs. 7.9%, p = 0.025). Genotype 1b was predominant. Incidence of cirrhosis was 7% among all participants. Conclusions: Mongols living in the USA are at high risk for CHB and CHC infections. One-third of CHB individuals had CHD superinfection with advanced fibrosis. Universal screening for viral hepatitis in Mongols in the USA is mandatory. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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