| Autor: |
Zhang, Xingqi, Li, Zequn, Sun, Yuqi, Liu, Gan, Liu, Xiaodong, Zhou, Yanbing |
| Předmět: |
|
| Zdroj: |
Cancer Management & Research; May2021, Vol. 13, p4055-4065, 11p |
| Abstrakt: |
Purpose: The present study aimed to examine the association of tumour necrosis factor-α-induced protein 8 (TIPE) expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Patients and Methods: The present study included 200 patients with colon cancer who underwent colon resection between June 2011 and October 2012. All follow-ups were censored in July 2020, with a median follow-up time of 62.25 months. Kaplan–Meier survival curve analysis and Cox regression analysis were used to determine predictors for the overall survival rate. Results: High expression of TIPE was associated with lymph node metastasis, higher Dukes' stage and right-sided colon cancer (RCC). An exploratory subgroup analysis found that high expression of TIPE was associated with age ≥ 65, lymphatic invasion and higher Dukes' stage only in the RCC group (P< 0.05), whereas no similar trend was observed in the left-sided colon cancer (LCC) subgroup. Age ≥ 65, differentiation, lymph node metastasis and TIPE expression levels were independent prognostic factors influencing the survival rate of patients with colon cancer following surgery in multivariate Cox analysis (P< 0.05). ROC curve analysis showed that the immunoreactive score of TIPE had good predictive value for five-year survival rates (AUC=0.727) and lymph node metastasis (AUC=0.760) among patients with RCC. Survival analysis revealed that the expression of TIPE had a significant impact on survival, and higher expression levels suggested a worse prognosis. Conclusion: This study demonstrated that TIPE may be a novel biomarker for predicting the survival outcome and lymph node metastasis. TIPE was overexpressed in colon cancer tissue and significantly associated with poor patient survival, especially in patients with RCC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
