| Autor: |
Kalsi, Jasjit S, Ralph, David J, Madge, David J, Kell, Phil D, Cellek, Selim |
| Předmět: |
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| Zdroj: |
International Journal of Impotence Research; Dec2004, Vol. 16 Issue 6, p479-485, 7p |
| Abstrakt: |
We compared the effects of a nitric oxide (NO)-releasing sildenafil (NCX-911), NO-independent soluble guanylate cyclase activator (BAY41-2272) and sildenafil on the anococcygeus muscle from streptozotocin-induced 16-weeks diabetic rats. NCX-911, BAY41-2272 and sildenafil reduced the phenylephrine-induced tone in the control group (EC50=1088.8±165.0, 151.6±9.3 and 827.1±167.3?nM, respectively). The potencies of NCX-911 and BAY41-2272 were not altered, but that of sildenafil was significantly reduced in the diabetic group. EC50 values for NCX-911, BAY41-2272 and sildenafil in the diabetic group were 1765.9±303.5, 209.7±27.3 and 2842.2±640.3?nM, respectively (P<0.05 for sildenafil). Nitrergic relaxation responses were significantly decreased in the diabetic group. The remaining nitrergic relaxation responses were potentiated by BAY41-2272 but not by sildenafil or NCX-911. These results confirm that endogenous NO derived from nitrergic nerves is significantly decreased in diabetes, and suggest that NO-releasing PDE5 inhibitors and NO-independent soluble guanylate cyclase activators could be more useful than PDE5 inhibitors in the treatment of ED in long-term diabetes.International Journal of Impotence Research (2004) 16, 479-485. doi:10.1038/sj.ijir.3901224 Published online 18 March 2004 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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