Association of Fetal MTHFR 677C > T Polymorphism with Non-Syndromic Cleft Lip with or without Palate Risk: A Systematic Review and Meta-Analysis.

Autor: Amooee, Abdolhamid, Dastgheib, Seyed Alireza, Niktabar, Seyed Mohammadreza, Noorishadkam, Mahmood, Lookzadeh, Mohamad Hosein, Mirjalili, Seyed Reza, Heiranizadeh, Naeimeh, Neamatzadeh, Hossein
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Zdroj: Fetal & Pediatric Pathology; Aug2021, Vol. 40 Issue 4, p337-353, 17p
Abstrakt: This study was conducted to estimate the precise association of fetal MTHFR 677 C > T polymorphism with risk of nonsyndromic cleft lip with or without cleft palate (NSCL ± P) using a large-scale meta-analysis. Methods: A comprehensive literature search was performed using studies published on PubMed, Science Direct, Scopus and CNKI databases up to November 1, 2019. Results: A total of 38 studies with 6,525 children with NSCL ± P and 8,606 controls were selected. Overall, there was a significant association between MTHFR 677 C > T polymorphism and NSCL ± P risk. Subgroup analysis by ethnicity revealed that MTHFR 677 C > T polymorphism contributed to development of NSCL ± P in Caucasian and Mixed populations, but not in Asians. When stratified by country of origin, we found a significant association in Brazilian, Turkish and Indian populations, but not in Chinese and US-American. Conclusions: This meta-analysis provides strong evidence that fetal MTHFR 677 C > T polymorphism is significantly associated with NSCL ± P risk. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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