N‐Methoxy arenesulfonamide as a Sulfonyl Equivalent For Palladium‐Catalyzed Sulfonylation of Arenes Through C−H Activation.

Autor:	Ojha, Subhadra, Panda, Niranjan
Předmět:	AROMATIC compounds ARYL bromides NATURAL products SCISSION (Chemistry) SULFONES ARYL iodides
Zdroj:	Asian Journal of Organic Chemistry; Jul2021, Vol. 10 Issue 7, p1665-1670, 6p
Abstrakt:	The prevalence of sulfones in natural products, pharmaceutically active molecules and functional materials draw immense attention for their synthesis. Here, we report a palladium‐catalyzed protocol for synthesizing diaryl sulfones from the arenes through C−H activation. N‐methoxy arenesulfonamide was exploited as a potential sulfonyl donor by the cleavage of S−N bond through a radical pathway. The present methodology has several advantages: a simple, readily available catalytic system; the use of a stable sulfonyl donor; a relatively moderate excess of arene coupling partner for an undirected C−H activation process, along with the tolerances of aryl bromides and iodides, which in turn permits further cross‐coupling reactions to afford cross‐coupled sulfones. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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