| Autor: |
Schwerzmann, Markus, Ruperti-Repilado, Francisco Javier, Baumgartner, Helmut, Bouma, Berto, Bouchardy, Judith, Budts, Werner, Campens, Laurence, Chessa, Massimo, del CerroMarin, Maria Jesús, Gabriel, Harald, Gallego, Pastora, Garcia-Orta, Rocio, Gonzalez, Ana Elvira, Schophuus Jensen, Annette, Ladouceur, Magalie, Miranda-Barrio, Berta, Morissens, Marielle, Pasquet, Agnes, Rueda, Joaquín, van den Bosch, Annemien E. |
| Předmět: |
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| Zdroj: |
Heart; Aug2021, Vol. 107 Issue 15, p1226-1232, 7p |
| Abstrakt: |
Aims: Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.Methods: Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.Results: Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).Conclusions: Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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