| Autor: |
Onoja, Remigius Ibe, Chukwudi, Chinwe Uzoma, Ugwueze, Emmanuel Uchechukwu, Anyogu, Davinson Chuka, Obidah, Wilson, Emesiani, Benjamin Ifechukwu |
| Předmět: |
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| Zdroj: |
Bulletin of the National Research Centre; 7/13/2021, Vol. 45 Issue 1, p1-7, 7p |
| Abstrakt: |
Background: Cadmium (Cd) is a known metallohormone which mimics the action of steroid hormones with adverse effect on testicular function. It is highly toxic and a prevalent environmental contaminant with no conventional antidote. This study investigates the possible ameliorative effects of Thymus vulgaris extract on testicular toxicity induced by Cd in male rats. Results: The testicular and epididymal weights, serum concentration of follicle stimulating hormone, luteinizing hormone, and testosterone were significantly (p ≤ 0.05) lower in the cadmium-treated group compared to the control. Necrosis of germ cells of the seminiferous tubules was observed in the testicular tissues of the cadmium-treated group. Administration of extract showed mild but non-significant (p ≥ 0.05) protective effect on the cadmium-induced decrease in sex hormones and sperm count as well as oxidative stress and histological changes. Conclusion: Thymus vulgaris leaf extract had weak ameliorative effect on cadmium-induced testicular injury in rats but with promising antioxidant activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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