| Abstrakt: |
Introduction. Endometriosis can be surgically induced in rats, which exhibit similar symptoms to humans (Günal et al., 2019). Materials and method. The data were taken from PubMed and included studies from the recent years. In the studies we selected, the researchers induced endometriosis by transferring endometrial tissue from the uterus to extrauterine areas. Results. In their study (Cuevas et al., 2018), the researchers induced endometriosis in female rats. In endometriosis areas, still degenerated mast cells were observed. Mast cell secreted proteases play an important role in fibrinogenesis and endometrial tissue migration (Cuevas et al., 2018). Free radical scavengers, such as melatonin and erythropoietin, have been found to reduce endometrial lesions by their antioxidant properties (Yildirim G, et al., 2010; Günal et al., 2019). In their study (Günal et al., 2019), the authors caused endometriosis in rats and after induction they administered estrogen to cause greater damage. In the group of rats administered by erythropoietin, endometrial foci and histopathological scores were both found to be reduced. After 20 days of erythropoietin treatment in rats, the lesions were further reduced (Chadha et al., 2008). Conclusions. Rats have been widely used in endometriosis models, as they show similar symptoms to humans. The accumulation of estrogen, the innervation of the hypothalamus and the oxygenation of the area through the development and differentiation of erythrocytes play an important role in the manifestation of symptoms. [ABSTRACT FROM AUTHOR] |
