| Autor: |
Kanellopoulos, Dimitrios, Karagianni, Dimitra, Pergialiotis, Vasilios, Patsouras, Grigorios, Patsouras, Konstantinos, Nikiteas, Nikolaos, Lazaris, Andreas C., Iliopoulos, Dimitrios |
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| Zdroj: |
Ginecologia.ro; Jul2021 Supplement S2, Vol. 9 Issue 32, p13-13, 1/2p |
| Abstrakt: |
Introduction. Endometriosis is a condition of female reproductive age where endometrial tissue (glands and layer) grows outside the uterus. Endometriosis is characterized by many researchers as an enigmatic disease and remains, even today, a serious condition that affects the quality of a woman’s life and her reproductive capacity. Endometriosis can be surgically induced in rats, which exhibit similar symptoms to humans. Materials and method. In our research, which was carried out at the Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, 24 female rats of Sprague Dowley® type, aged 3 months old and weighing 170-200 grams, were used for the development of an animal model for the study of endometriosis. Living and handling conditions were in line with Presidential Decree 160/91, which governs the protection of animals used for research purposes. All rats were deprived of food 12 hours before surgery. On the day of surgery, they were randomly divided into four groups, consisting of six rats each. Group A consisted of healthy female rats (control group). Group B consisted of rats with ovarian endometriomas. Group C consisted of rats with disseminated intraperitoneal endometriosis, while Group D consisted of rats with extraperitoneal endometriosis. In groups B, C and D, the disease was experimentally induced by transplanting fragments of endometrial tissue into ectopic sites Conclusions. In our experimental model, we observed that endometriosis affects fertility by reducing the number of follicles. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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