Effects of Complement Regulators and Chemokine Receptors in Type 2 Diabetes.

Autor:	Aydin Ozgur, B, Coskunpinar, E, Bilgic Gazioglu, S, Yilmaz, A, Musteri Oltulu, Y, Cakmakoglu, B, Deniz, G, Gurol, AO, Yilmaz, MT
Předmět:	TYPE 2 diabetes CHEMOKINE receptors CARDIOVASCULAR diseases CD55 antigen CD59 antigen
Zdroj:	Immunological Investigations; Jul2021, Vol. 50 Issue 5, p478-491, 14p
Abstrakt:	CD55 and CD59 are complement regulatory proteins suggested to be related with progression of diabetes and its complications. The stromal cell-derived factor 1 (SDF-1) and C-X-C chemokine receptor type 4 (CXCR-4) are chemokine proteins. We aimed to investigate the relation of CD55 and CD59 expression levels and polymorphisms of SDF-1 and CXCR-4 with type 2 diabetes mellitus (T2DM) and its complications. Seventy-five T2DM patients and 73 controls were enrolled. Expression levels of CD55 and CD59 were measured by FACS Calibur; qRT-PCR was used to determine SDF-1 and CXCR-4 gene polymorphisms. CD55 and CD59 expressions in patients with nephropathy, retinopathy and cardiovascular disease were significantly lower than controls. Frequency of CXCR-4 T allele carrying was high in patients and created 1.6 fold risk for the disease (p =.07). CXCR-4 a allele carriers had decreased nephropathy; although there was no statistical significance in carrying CXCR-4 T allele, presence of nephropathy was approximately 2 times higher (p =.254). The nephropathy risk increased 10-fold in CXCR-4 TT genotype carriers (p =.02). All SDF-1 CC genotype carriers had retinopathy, so, it was considered that the CC genotype was effective in retinopathy development (p =.031). For the presence of cardiovascular disease, significant difference was observed for SDF-1 genotypes. Increased cardiovascular risk of 5- and 1.9-fold in SDF-1 T (p =.007) and CXCR-4 T (p =.216) allele carriers, respectively, was observed. We suggest that CD55 and CD59 protein levels and SDF-1 and CXCR-4 have predictive importance in process, complications and tendency of T2DM. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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