Influence of irisin on diet-induced metabolic syndrome in experimental rat model.
| Autor: | Medhat, Dalia, El-Bana, Mona A., El-Daly, Sherien M., Ashour, Magdi N., Elias, Tahany R., Mohamed, Rehab A., Yassen, Noha N., Abdel-Monem, Mahmoud A., Hussein, Jihan |
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| Předmět: |
KIDNEY physiology
LIPID analysis THERAPEUTIC use of cytokines FIBRONECTINS CYTOKINES BIOLOGICAL models FASTING PANCREAS FAT content of food SKELETAL muscle FATTY liver ANIMAL experimentation LIVER DIET CARBOHYDRATE content of food BLOOD sugar PEROXISOME proliferator-activated receptors RATS INSULIN GENE expression METABOLIC syndrome POLYMERASE chain reaction AORTA CARRIER proteins |
| Zdroj: | Journal of Complementary & Integrative Medicine; Jun2021, Vol. 18 Issue 2, p347-354, 8p |
| Abstrakt: | To evaluate the influence of irisin on the experimental paradigm of non-alcoholic fatty liver (NAFL) as a part of MetS cluster. Forty male albino rats were divided into four groups; normal control, standard diet + irisin, high carbohydrate and fat diet (HCHF), and HCHF + irisin. After the experimental period, levels of fasting blood sugar (FBS), insulin, lipid profile, kidney functions, salusin-alpha (Sal-α), adropin, and retinol-binding protein-4 (RBP-4) were evaluated. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α) expression in skeletal muscle was evaluated by quantitative real-time PCR. Aorta, liver, pancreas, and skeletal muscle tissue samples were prepared for histopathological examination. Rats administrated HCHF showed elevated levels of FBS, lipid profile, kidney functions, RBP-4, and downregulation of PGC-1α expression along with a decline in levels of insulin, Sal-α, and adropin while administration of irisin significantly attenuated these levels. Irisin as based therapy could emerge as a new line of treatment against MetS and its related diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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