| Autor: |
Castelein, Stynke, Timmerman, Marieke E., PHAMOUS investigators, Arends, Johan, Bartels-Velthuis, Agna A., Bruggeman, Richard, Jörg, Frederike, Pijnenborg, Gerdina H.M., Knegtering, Henderikus, Veling, Wim, Wunderink, Alex, van der Gaag, Mark, Visser, Ellen |
| Předmět: |
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| Zdroj: |
British Journal of Psychiatry; Jul2021, Vol. 219 Issue 1, p401-408, 8p |
| Abstrakt: |
Background: Recovery in schizophrenia is a complex process, involving clinical, societal and personal recovery. Until now, studies analysed these domains separately, without examining their mutual relations and changes over time.Aims: This study aimed to examine different states of recovery and transition rates between states.Method: The Pharmacotherapy Monitoring and Outcome Survey (2006-2017) yearly assesses patients with schizophrenia in the Northern Netherlands. Data from 2327 patients with one up to 11 yearly measurements on clinical, societal and personal recovery were jointly analysed with a mixture latent Markov model (MLMM).Results: The selected MLMM had four states that differed in degree and pattern of recovery outcomes. Patients in state 1 were least recovered on any domain (16% of measurements), and partly recovered in states 2 (25%; featured by negative symptoms) and 3 (21%; featured by positive symptoms). Patients in state 4 (38%) were most recovered, except for work, study and housekeeping. At the subsequent measurement, the probability of remaining in the same state was 77-89%, transitioning to a better state was 4-12% and transitioning to a worse state was 4-6%; no transitions occurred between states 1 and 4. Female gender, shorter illness duration and less schizophrenia were more prevalent in better states.Conclusions: Quite a high recovery rate was present among a substantial part of the measurements (38%, state 4), with a high probability (89%) of remaining in this state. Transition rates in the other states might increase to a more favourable state by focusing on adequate treatment of negative and positive symptoms and societal problems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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