| Autor: |
Fadlan, Arif, Prayitno, Budi, Fahmi, Muhammad R. G., Santoso, Mardi, Kusumawati, Yuly, Purnomo, Adi Setyo |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2020, Vol. 2349 Issue 1, p1-6, 6p |
| Abstrakt: |
The synthesis of indolin-2-one derivatives and in vitro anticancer activity on colon cancer were reported in the present study. The compounds contain a fluorine or a bromine in position 5, and a bromine in position 7. The results established that indolin-2-one with bromine in position 5 gave up to a 4-fold improved cytotoxicity over indolin-2-one with fluorine in position 5. The indolein-2-one with bromine in posititon 5 also exerted higher cytotoxicity compared to bromine in position 7. This work highlights the importance of halogen and their position in cytotoxicity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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