Kinetic and polarographic study on atropine N-oxide: its obtaining and polarographic reduction.

Autor: Dubenska, Liliya, Dushna, Olha, Blazheyevskiy, Mykola, Pysarevska, Solomiya, Klymiuk, Iryna
Zdroj: Chemical Papers; Aug2021, Vol. 75 Issue 8, p4147-4155, 9p
Abstrakt: The work presents the obtaining of atropine N-oxide using various peroxyacids (organic monoperoxyacid, diperoxyacids and inorganic peroxyacids). The kinetics of atropine oxidation with various oxidants, for example Oxone, m-chloroperoxybenzoic acid, diperoxysebasic acid and diperoxyazelaic acid, was studied. The optimal conditions for obtaining of atropine N-oxide (oxidation duration, pH) are given in the work. It was established that the best oxidant was potassium peroxymonosulfate, since 100% yield of atropine N-oxide was achieved within 15 min. In this work, we showed that the oxidation reaction of atropine to N-oxide was a second-order reaction. The rate constants of these reactions were established. The electrochemical behavior of atropine N-oxide obtained using potassium peroxymonosulfate and m-chloroperoxybenzoic acid on a mercury dropping electrode was investigated. Atropine N-oxide was reduced forming two peaks. Each reduction peak involved 1 electron and 1 proton. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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