Ventral hernia repair using allogenic acellular dermal matrix in a swine model.

Autor:	Silverman, R., Li, E., Holton, L., Sawan, K., Goldberg, N., Silverman, R P, Li, E N, Holton, L H 3rd, Sawan, K T, Goldberg, N H
Předmět:	GRAFT versus host disease VENTRAL hernia ABDOMINAL wall FASCIAE (Anatomy) OPERATIVE surgery POLYTEF COLLAGEN HERNIA surgery THERAPEUTIC use of biomedical materials ANIMAL experimentation BIOLOGICAL models COMPARATIVE studies RESEARCH methodology MEDICAL cooperation RESEARCH SUTURING SWINE EVALUATION research TREATMENT effectiveness ARTIFICIAL skin TENSILE strength SURGICAL meshes THERAPEUTICS
Zdroj:	Hernia; Dec2004, Vol. 8 Issue 4, p336-342, 7p
Abstrakt:	Background: This study was designed to assess the long-term efficacy of allogenic acellular dermal matrix (ADM) used as an interpositional graft for ventral hernia repair in a swine model.Methods: We created 12x4-cm full-thickness abdominal wall defects in 22 Yucatan miniature pigs. The defect was repaired with either two 6x4-cm pieces of AlloDerm (acellular dermal matrix processed from pig skin in order to avoid a xenogenic response, LifeCell Corporation, Branchburg, NJ USA) (n = 12), or expanded polytetrafluoroethylene mesh (ePTFE) (Gore-Tex, W.L. Gore & Associates, Inc., Newark, DE USA) (n = 10). In six pigs, a separate 3-cm fascial incision was made, which was then suture repaired as a control for tensiometry testing. The surgical sites were evaluated at either 3 months or 9 months for the presence of a hernia, stretching of the implant, adhesions, vascularity, and biomechanical strength.Results: Two hernias occurred in both the ADM and the ePTFE groups. There was minimal stretching of the implants and minimal adhesions in both groups. Fluorescein testing and histology indicated vascular ingrowth into the ADM. There was no statistical difference between the mean breaking strengths of the ADM-fascial interface (106.5 N +/- SD 40.1), the interface between two pieces of ADM (149.1 N +/- SD 76.7), and the primary fascial repair (108.1 N +/- SD 20.9) at 9 months. The ADM-fascial interface had a significantly higher breaking strength than that of the ePTFE-fascia interface (66.1 N +/- SD 30.1) (P = 0.017, t-test, P = 0.043 Wilcoxon rank sum test).Conclusions: In this study, we were unable to demonstrate a difference between ADM and ePTFE in their ability to repair ventral hernias at 9 months in a swine model. The ADM additionally supports vascular ingrowth and exhibits increased breaking strength at the fascia-implant interface. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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