| Autor: |
Mawarti, Herin, Nugraha, Jusak, Purwanto, Djoko Agus, Soeroso, Joewono |
| Předmět: |
|
| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Apr-Jun2021, Vol. 15 Issue 2, p2488-2494, 7p |
| Abstrakt: |
Objective: This study aims to investigate the effects of green tea administration on TNF-a, Hsp70, and TGF-b1 levels in the systemic lupus erythematosus (SLE). Material and methods: A total of 32 mice will be divided into four groups (each 8 mice), namely the control group, the SLE group, the SLE group who were given green tea extract at a dose of 500 mg/kg body weight, and the SLE group who were given green tea extract at a dose of 1000 mg/kg body weight. Analysis of TNF-a, Hsp70, and TGF-b1 levels was carried out using the enzyme-linked immunosorbent assay technique. Results: TNF-a and TGF-b1 levels were significantly increased in the SLE group compared to the control group (p < 0.05). This increase can be significantly reduced through the provision of green tea, even reaching levels comparable to the control group (p > 0.05). Conclusions: It was concluded that green tea containing EGCG can suppress TNF-a and TGF-b1 in the SLE model. Thus, green tea can be an alternative in immunology modulation in SLE. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
