The Effect of Artemisia Dracunculus L. on Mitotic Index in Bone Marrow and Spleen Cells of Mice: In Vivo Study.

Autor: Jwaid, Ahmed Hamed, Hassan, Ali Faris, Kasim, Ali Abdulhussain
Předmět:
Zdroj: Indian Journal of Forensic Medicine & Toxicology; Apr-Jun2021, Vol. 15 Issue 2, p1879-1883, 5p
Abstrakt: Artemisia dracunculus L. (tarragon) is a rich source of herbal remedies with antioxidant and anti-inflammatory properties. In the present study, the proliferation of bone marrow and spleen cells of mice was evaluated after extraction of Artemisia dracunculus with 80% of ethanol. Two doses of the extract (500mg/kg body weight and 1000mg/kg body weight) were given to the mice for seven successive days. On day eight, mice were sacrificed and cells from bone marrow and spleen were collected; mitotic index was calculated and results were compared with that of methotrexate at a dose 20mg/kg body weight ( positive control ) and distilled water ( negative control). The results showed that the dose 500mg/kg body weight of Artemisia dracunculus extract caused significant increase in mitotic index in both bone marrow and spleen cells of mice when compared with negative control. While, the dose 1000mg/kg body weight of Artemisia dracunculus extract caused significant decrease in mitotic index in both bone marrow and spleen cells of mice when compared with negative control. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index