| Autor: |
Wahyu, Sri, Hamid, Firdaus, Hatta, Mochammad, Djawad, Khairuddin, Bukhari, Agussalim, Natzir, Rosdiana, Baharuddin, Alfina |
| Předmět: |
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| Zdroj: |
Indian Journal of Forensic Medicine & Toxicology; Apr-Jun2021, Vol. 15 Issue 2, p1609-1614, 6p |
| Abstrakt: |
The aim of this study was to test the effectiveness of secang wood extract (Caesalpinia sappan L) on IL-6 and IL-10 expression in Balb / c mice with vulvovaginalis candidiasis. This type of research is an experimental laboratory, with a control group design using experimental animals as research objects. The research subjects were BALB / c mice weighing 35-40 grams, aged 10-12 weeks, the number of experimental animals needed in this study was 18 for 3 random groups, each group being 6. Analysis and data processing using the excel program SPSS Repeated ANOVA Test was used to measure differences in cytokine levels. IL-6 levels in group 1 (control) where the value of IL-6 expression after infection (H1) was 4309.40 pg /mL (IQR value 3803.8-4963.5) after treatment (H7) in the control group increased by 5578.12 pq / mL (IQR 5330.3 - 6162.9). In group 2 that were given fluconazole and secang wood extract, IL-6 levels tended to decrease by 3516.4 pq / mL (IQR: 3070.4-4061.6) Secang wood after infection decreased from 3417.34 pq / mL to 2782.97 pq / mL after treatment. In Group 2 that was given fluconazole and secang wood extract, IL-10 levels increased by 1414.8 pq / ml (IQR: 1061.7- 3158) after infection, to 3268.35 pq / ml (IQR value: 1789.9-3709.6) after treatment. given secang wood after infection increased from 2032.67 pq / ml to 3091.83 pq / mL after treatment. The p value is 0.008. Obtained the effect of secang wood extract in reducing levels of Interleukin 6 and can increase the value of IL-10 levels after administration of secang wood extract on candidiasis vulvovaginalis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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