Influence of the Recombinant Heat Shock Protein 90β (HSP90β) on the Wound Healing Rate in Mice.

Autor:	Zhalimov, V. K., Skarga, Y. Y., Gritsyna, Yu. V., Morenkov, O. S.
Předmět:	HEAT shock proteins WOUND healing CELL migration MICE
Zdroj:	Biology Bulletin; May2021, Vol. 48 Issue 3, p351-357, 7p
Abstrakt:	It is known that the alpha isoform of heat shock protein 90 (HSP90α) plays an important role in wound healing. HSP90α has a stimulating effect on migration and invasion of cells in the wound area. The role of beta isoform of HSP90 (HSP90β) in wound healing has not been fully determined. Recombinant human HSP90β expressed in E. coli has been obtained and characterized in the present work. By using an excision model of wound healing in mice, it was shown that purified recombinant human HSP90β introduced into the wound area increases the rate of wound healing by 28% compared to the control. This fact allows HSP90β to be considered a promising drug for wound healing. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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