Silica sulfuric acid catalyzed green synthesis of 1,2-dihydro-1-aryl naphtho[1,2-e][1,3]-oxazin-3-one and 1,2-dihydro-1-methyl naphtho[1,2-e][1,3]-oxazin-3-one as potent antibacterial agents.

Autor: Zhimomi, Betokali K., Imchen, Putusenla, Thurr, Metsütu, Lensayula, Tumtin, Shokip, Phucho, Tovishe
Předmět:
Zdroj: Indian Journal of Chemistry. Sect B; Apr2021, Vol. 60B Issue 4, p598-604, 27p
Abstrakt: A simple, efficient and green method for the preparation of naphthooxazinones employing easily available reagents 2-naphthol, aldehydes, urea and silica sulphuric acid (SSA) as catalyst is reported. The microwave assisted multi component reaction (MCR) procedure provides multiple advantages inclusive of short reaction times, high yields, easy work-up, catalyst recovery and reusability which proves to be environmentally benign. Studies on the antibacterial properties of the synthesized heterocyclic compounds have been done through in vitro methods against gram-positive and gram-negative bacteria. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index