| Autor: |
Muraoka, Kenichi, Yoshida, Satoshi, Hasegawa, Kazumasa, Nakanishi, Nobuo, Fukuzawa, Isao, Tomita, Akio, Jong Chol Cyong |
| Předmět: |
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| Zdroj: |
Journal of Alternative & Complementary Medicine; Oct2004, Vol. 10 Issue 5, p841-849, 9p |
| Abstrakt: |
Objective: The phagocytic activity of macrophages as a novel approach to scientific elucidation of the effects of Chinese medicines was studied through administration of a kampo preparation, by measuring the rise in body temperature, which is thought to stimulate innate defensive functions of organisms and enhance the immune systems. Design: Using dogs as experimental models, a rise in body temperature following administration of Kakkon- to was observed, and the average number and average rate of phagocytosis of macrophages in blood using latex micro-particles was investigated. Results: The body temperature of the treated animals significantly increased 30 minutes after administration (p <0.01), and remained elevated for more than 5 hours. A comparison of body temperatures before and after administration showed significant increases over controls from 1 to ii hours, p < 0.01; and at 12 hours, p < 0.05 after administration. The average number and the average rate of phagocytosis were significantly in- creased 1 (p < 0.05) and 2 (p <0.01) hours after administration. The mean number of phagocytized cells significantly increased (p <0.05) at 1 hour after administration compared with that before administration, and the mean phagocytic rate also increased significantly (p <0.01) 2 hours after administration. Increases (p < 0.01) in both the rate of phagocytosis and the number of cells phagocytized were found at every measurement point from 2 to 24 hours after administration. Significant increases (p < 0.01) were also observed in both the rate of phagocytosis and the number of cells phagocytized 3 hours after administration, when compared with the con- trol group. Conclusion: This paper demonstrates that ingestion of Kakkon-to not only increases the body temperature but also enhances the phagocytic activity of macrophages, an in vivo defense mechanism, suggesting that Kakkon-to contributes to the suppression of multiplication of common cold viruses and influenza viruses, which consequently results in improvement of various symptoms during infection with common cold viruses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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