| Autor: |
Di Scala, Emmanuella, Rose, Stéphanie, Hérault, Olivier, Argibay, Jorge, Cosnay, Pierre, Bozon, Vèronique |
| Předmět: |
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| Zdroj: |
Receptors & Channels; May-Aug2004, Vol. 10 Issue 3/4, p125-129, 5p |
| Abstrakt: |
The initial objective of this work was to examine the effects of an antibody (Anti-G21V) directed against the second extracellular loop of human heart 5-HT4receptors expressed in Chinese hamster ovary (CHO) cells. The antibody anti-G21V had no effect upon either basal cAMP–or 5-HT–evoked increases in cAMP in CHO cells, whereas it had shown an agonist-like effect in COS-7 cells. Analysis of agonist fractions of h5-HT4(e)receptors in CHO and COS-7 cells revealed that equilibrium constant could underlie the different responses of the receptor toward the anti-G21V antibody. Therefore, different expression systems could give rise to functional differences in 5-HT4receptor behavior. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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