| Autor: |
Freitas Dutra, Valeria, Bonet‐Bub, Carolina, Yokoyama, Ana Paula H., Achkar, Ruth, Machado, Rafael Rahal Guaragna, Assunção, Murilo, Candelária, Gabriela, Soares, Camila Pereira, Fachini, Roberta Maria, Fontão‐Wendel, Rita, Hamerschlak, Nelson, Reis, Luiz Fernando Lima, Araujo, Danielle Bastos, Nudelman, Victor, Pinho, Joao R. R., Rizzo, Luiz V., Sakashita, Araci M., Scuracchio, Patrícia, Durigon, Edison Luiz, Wendel, Silvano |
| Předmět: |
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| Zdroj: |
Vox Sanguinis; May2021, Vol. 116 Issue 5, p557-563, 7p, 4 Charts, 2 Graphs |
| Abstrakt: |
Background: Blood groups and anti‐A isohemagglutinin may be involved in susceptibility to SARS‐CoV‐2 infection. Materials and Methods: We retrospectively studied 268 COVID‐19 convalescent plasma donors and 162 COVID‐19 inpatients (total 430 subjects, confirmed by RT‐PCR) and 2,212 healthy volunteer first‐time blood donors as a control group. These were further divided into two groups: those with anti‐A (blood types O and B) and those without it (types A and AB). Titres of nucleoproteins, and neutralizing SARS‐CoV‐2 antibody were measured in the convalescent plasma donors and inpatients. Multivariate logistic regression and non‐parametric tests were applied. Results: Persons having types O or B showed less infection prevalence than those of types A or AB (OR = 0·62, 95% CI 0·50–0·78; P < 0·001), but there was no difference when COVID‐19 inpatients were analysed. Immunoglobulins M, G and A were lower in COVID‐19 subjects of types O or B group than those of A or AB (0·16 vs. 0·19; P = 0·03, 2·11 vs. 2·55; P = 0·02, 0·23 vs. 0·32; P = 0·03, respectively). Conclusion: In this retrospective cohort, COVID‐19 individuals were less likely to belong to blood types O and B, and also had lower SARS‐CoV‐2 antibody titres than A and AB individuals. COVID‐19 severity did not associate with the blood groups. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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