| Autor: |
Kon, Kazumasa, Takai, Hiromu, Kobayashi, Takumu, Kohari, Yoshihito, Murata, Miki |
| Předmět: |
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| Zdroj: |
Synlett; 2021, Vol. 32 Issue 8, p829-832, 4p |
| Abstrakt: |
An organocatalyzed asymmetric aldol reaction of α-keto amides was developed. An N-terminal 4- trans -siloxyproline-based tripeptide with an l - tert -leucine unit adjacent to the 4- trans -siloxyproline residue was used to catalyze the reaction between various α-keto amides and acetone, to produce the corresponding aldol adducts with up to 99% yield and 91% ee. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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