| Autor: |
Wilches, Isabel, Jiménez-Castillo, Priscila, Cuzco, Nancy, Clos, M. Victoria, Jiménez-Altayó, Francesc, Peñaherrera, Eugenia, Jerves-Andrade, Lourdes, Tobar, Vladimiro, Vander Heyden, Yvan, Leon-Tamariz, Fabián, Vila, Elisabet |
| Předmět: |
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| Zdroj: |
Natural Product Research; May2021, Vol. 35 Issue 10, p1657-1661, 5p |
| Abstrakt: |
Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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